Launched in 2023, CRISPR Cures for Cancer is a tri-institutional initiative to accelerate cell therapy design and development using genomic technologies. This program unites researchers at UCSF, Gladstone Institutes, and the Innovative Genomics Institute at UC Berkeley to accelerate the development of novel therapies for a wide variety of cancers by combining genetic discovery and design with innovations in CRISPR technology. By directly funding investigators, collaborative projects, and technology platforms, our integration of research and discovery with therapeutic process development and clinical trials is designed to allow us to rapidly move innovations to clinical translation after discoveries are made.